Current Research Studies

1. Title: Determinants of Upper Extremity Functional Capabilities in Tetraplegia

Purpose: This study is intended to enhance the understanding of what constitutes a clinically meaningful change in upper extremity neurological function after cervical spinal cord injury. We will examine relationships among neurologic function, upper extremity capabilities, use of adaptive equipment, and performance of self-care and fine motor skills.

Principle Investigator: Ralph J. Marino, MD


2. Title: Understanding Experiences of Individuals with Spinal Cord Injury Undergoing Activity-Based Rehabilitation

Purpose: The purpose of this research is to understand the experiences of individuals with spinal cord injury related to activity-based rehabilitation for upper limb training.

Principle Investigator: Ralph J. Marino, MD


3. Title: AXER-204 in Participants with Chronic Spinal Cord Injury (RESET): Part 2 - a multicenter, randomized, double-blind, placebo-controlled, repeat dose study in chronic cervical spinal cord injury participants

Purpose: To evaluate the safety, tolerability, pharmacokinetics, and efficacy of repeated doses of AXER-204 administered by lumbar puncture and slow bolus infusion in comparison to placebo.

Principle Investigator: Ralph J. Marino, MD


4. Title: The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury (Up-LIFT)

Purpose: This is a prospective, single-arm study designed to evaluate the safety and effectiveness of non-invasive electrical spinal cord stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in people with chronic tetraplegia.

Principle Investigator: Ralph J. Marino, MD


5. Title: Development of the Spinal Cord Injury Movement Index

Purpose: To develop a new assessment tool to measure movement and recovery for individuals with spinal cord injury (all levels).

Principle Investigator: MJ Mulcahey, PhD



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